Raddel

Press note: " A novel anticancer therapy system based on carbon nanocapsules"

A press note has been released by RADDEL network after the publication of a paper in Nanoscale based on the development of antibody-funcionalised carbon nanotubes filled with radioactive metals. The news have been highlighted in several media:

R+D CSIC

ICN2

La Razón

La Vanguardia

 

Here is the full extract of the press note:

"Researchers from the Materials Science Institute of Barcelona (ICMAB-CSIC) in collaboration with the Catalan Institute of Nanoscience and Nanotechnology (ICN2), the Institute of Molecular and Cellular Biology (IBMC-CNRS) and King’s College London (KCL) have developed a novel nanocarrier anti-cancer platform for the targeted delivery of radioactivity. The results, published in the journal Nanoscale, are part of a collaborative Marie-Curie Initial Training Network (ITN) (RADDEL), funded by the European Commission FP7 and coordinated by Dr. Gerard Tobias from the ICMAB-CSIC.

RADDEL aims to develop novel diagnostic and therapeutic tools based on nanocapsules in the form of filled carbon nanotubes.

Carbon nanotubes have already found many applications, being the most prominent one their use in composite materials for sport goods, which are commercially available. They are also attractive nanoplatforms in the biomedical field with a variety of applications that range from scaffolds to drug delivery vehicles. In this area, their use as radionuclide carriers for imaging and therapeutic purposes has been very limited.

Whereas the nanotube’s internal cavities offer a suitable environment for the encapsulation of payloads of interest, their high external surface can be used for the anchoring of targeting functionalities, thus providing selectivity to the nanocarriers.

In this study, the collaborators have combined the endohedral and exohedral modification of carbon nanotubes to design a novel targeted anticancer therapy system. The nanotubes were filled with the model non-radioactive materials SmCl3 and LuCl3 and sealed, followed by the external functionalization with the monoclonal antibody Cetuximab. Cetuximab targets Epidemial growth factor receptors (EGFR) that are overexpressed by several cancer cells. 

The targeting efficacy was assessed in vitro for U87 EFGR+ cancer cells, and the nanocarrier was able to selectively accumulate into the cancer cells with no significant cytotoxicity observed. These results open up new frontiers in the development of novel nanomaterials for biomedical applications in the areas of cancer diagnosis and therapy. The network is currently assessing the in vivo performance of these nanocarriers by using the equivalent hot radioactive compounds."

Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

RADDEL project:  http://projects.icmab.es/raddel/

Reference article:

C. Spinato, A. P. Ruiz de Garibay, M. Kierkowicz, E. Pach, M. Martincic, R. Klippstein, M. Bourgognon, J. T-W. Wang, C. Ménard-Moyon, K. T. Al-Jamal, B. Ballesteros, G. Tobias, A. Bianco; Design of antibody-functionalized carbon nanotubes filled with radioactivable metals towards a targeted anticancer therapy; Nanoscale, DOI: 10.1039/C5NR07923C (2016).

The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement n° 290023.

esquema nanotubos RADDEL

 

 

Pictures from Nanobioapp2015 Conference

The conference Nanobioapp2015 "Latest Advances on Nanomaterials for Biomedical Applications" took place last September at the Casa de Convalescencia in Barcelona. The aim of the conference was to discuss the latest advances in the areas of biomedical imaging, therapy, monitoring, tissue repair and engineering, scaffolds, cellular growth, biosensors, and radiopharmaceuticals amongst others. Invited speakers included:

-Prof. Maurizio Prato (Univ. Trieste, Italy);

-Prof. Gustaaf Van Tendeloo (Univ. Antwerp, Belgium);

-Prof. Luis M. Liz-Marzán (CIC biomaGUNE, Spain);

-Prof. Jaume Veciana (ICMAB-CSIC, Spain);

-Prof. Víctor Puntes (ICN2, Spain);

-Dr. Alberto Bianco (IBMC-CNRS, France);

-Prof. Stefan Jakobs (Max Planck Institute for Biophysical Chemistry, Germany);

-Prof. Twan Lammers (EXMI-RWTH, Germany);

-Dr. Jose Antonio Garrido (TUM, Germany);

-Dr. Emmanuel Flahaut (CIRMAT-CNRS, France);

-Prof. Uday Kompella (Univ. Colorado, USA);

-Dr. Biqiong Chen (Univ. Sheffield, UK)

The conference was a total success, with more than 100 participants from 15 different countries. The local Organising Committee and the Scientific Committee of Nanobioapp2015 would like to thank all the conference participants. A special acknowledgement goes to all the attendants contributing with keynote, invited and oral talks; the scientific level of the conference was very high and we hope you all enjoyed it as much as we did. A big thank you also to the participants in the poster session. Here you can see some of the pictures from the conference:

 

Nanobioapp 1 
 Nanobioapp 2
 Nanobioapp 3
 Nanobioapp 4

Fellows from ICMAB-CSIC participate in the exhibition "Nanoscience: so small and so close"

Panormica

 

The Barcelona Nanotechnology Cluster (bnc-b) and the Catalan Institute of Nanotechnology (ICN2) in collaboration with several research institutes located in the Bellaterra campus of the Autonomous University of Barcelona (UAB) is organising the exhibition about nanoscience: "Nanoscience: so small and so close". The exhibition is being held at the Library of the Department of Science.

Several research groups of the Institute of Materials Science of Barcelona (ICMAB-CSIC) are participating in the exhibition, highlighting the amount and quality of nano research being carried out in the campus at the moment. RADDEL fellows Markus Martincic and Adem Güven have collaborated by preparing some contents for this exhibition related to the use of carbon nanotubes for biomedical applications, and in particular for cancer therapy and diagnosis, the topic of RADDEL project.

ICMAB Ficha ICMAB
ICMAB 2

 More pictures can be found here

 

 

RADDEL fiches: Cancer Therapy (6)

Fiche 6 is for Cancer Therapy. It includes some basic information about what cancer is and its different causes, the current types of cancer with major incidence and a brief explanation on the most important cancer treatments available nowadays. Remember that these Fiches are being prepared by the fellows as part of their training programme.

  Fiche06a

                             Fiche06b                          

You can download this Fiche here.

RADDEL fiches: Drug Delivery (5)

After the summer break we go back to our series of RADDEL Fiches, which are being prepared by the fellows participating in the training programme with the aim of explaining the basics of the topics related to the project to the non-specialised audience. Our next Fiche is related with Drug Delivery, including its definition, types of drug carriers available nowadays and a practical example on how a drug delivery system with decorated nanotubes works.

  Fiche05a

                             Fiche05b                          

You can download this Fiche here.

RADDEL fiches: Spectroscopy (4)

Spectroscopy is the topic for our new RADDEL Fiche, explaining the concept behind this characterization technique based on the electromagnetic spectrum and giving a few examples which highlight the importance of spectroscopy in our daily lifes. These Fiches are being prepared by the recruited RADDEL fellows working in the project as part of their personal training programme.

  Fiche04a

                             Fiche04b                           

You can download this Fiche here.

RADDEL fiches: Pharmacology (3)

It is the turn for Pharmacology in this month's Fiche. It gives a clear and concise explanation about what pharmacology is and a brief history, along with the different routes of administration and the pharmacological effects of drugs. These Fiches are being prepared by the recruited RADDEL fellows working in the project as part of their personal training programme.

  Fiche03a

 

                             Fiche03b

 

                              

You can download this Fiche here.

RADDEL fiches: Nanomedicine (2)

Following the success of our first Fiche, which the Marie Curie Actions facebook profile mentioned as "a good example of outreach activity", we present today the second Fiche related to Nanomedicine. It gives a clear and concise explanation about what nanomedicines are and their wide range of applications.

Remember that these Fiches are prepared by the RADDEL fellows working in the project as part of their personal training programme.


  Fiche02a

                                                            Fiche02b

You can download this Fiche here.

RADDEL fiches: Carbon Nanotubes (1)

As part of the dissemination and outreach activities within the project, and with the aim of approaching the non-scientific community in order to present them with the main concepts and implications of RADDEL, a series of Fiches dedicated to topics related to the training network will be available at the website. General topics like Nanomedicine, Drug Delivery, Cancer Therapy, Pharmacology, Microscopy, and other more specific to the project like Carbon Nanotubes, Carbohydrates or Molecular Simulation will be presented in a way that it can be readable by the non-expert in the fields of the project. These Fiches are prepared by the fellows working in the project as part of their training programme. We hope you will enjoy them. 

For the first Fiche, we have Carbon Nanotubes. It gives a brief introduction about what CNTs are, how they look like and finally some properties and applications.

 

Fiche01a
Fiche01b

You can download this Fiche here.

Dr. Gerard Tobias (ICMAB-CSIC), member of the nanoDYF network

Dr. Gerard Tobias from ICMAB-CSIC, and coordinator of the RADDEL project, is a member of nanoDYF, a Spanish network for dissemination, outreach and training activities in Nanotechnology.

More information:

nanoDYF