A collaborative paper between RADDEL partners KCL and EMAT, published in ACS Nano

R. I. El-Gogary, N. Rubio, J. T-W. Wang, W. T. Al-Jamal, M. Bourgognon, H, Kafa, M. Naeem, R. Klippstein, V. Abbate, F. Leroux, S. Bals, G. Van Tendeloo, A. O. Kamel, G. A. S. Awad, N. D. Mortada, K. T. Al-Jamal 

Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo

ACS Nano, 8, 1384-1401 (2014)


In this paper, the formulation and characterization of chemically modified polymeric nanocapsules incorporating the anticancer drug quercetin for the passive and active targeting to tumours is described. The developed nanocapsules provide a system for targeted delivery of a range of hydrophobic anticancer drugs in vivo. RADDEL partners KCL and EMAT have participated in this study that provide new insights into the in vivo behaviour of nanocapsules.